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This is precisely why pharmacovigilance, real-world evidence, and predictive safety assessment remain essential components of modern drug development and patient care

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This observation prompted the authors to consider whether the protective mechanism of A1AT involves not only the direct inhibition of NE activity but also an anti-inflammatory effect that prevents the release of TNF- alpha and subsequent infiltration of inflammatory cells

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For neuro-PASC, the therapeutic potential of 31 phytochemicals (derived from 19 medicinal herbs) to resolve neuro-cognitive impairments such as anxiety, depression , mixed anxiety-depressive (MAD) syndromes, and irreversible dementia has been reported 770